![]() ![]() Chemoprevention of basal and squamous cell carcinoma with a single dose of flourouracil, 5%, cream: A randomized clinical trial. Tolak (fluorouracil) cream, 4%, for topical use.Skin cancer treatment (PDQ)–Patient version. ![]() Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. Local treatment other than surgery for basal and squamous cell skin cancers.Topical chemotherapy in cutaneous T-cell lymphoma: Positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. Combination topical chemotherapy for the treatment of an invasive cutaneous squamous cell carcinoma. Topical and intralesional treatment of nonmelanoma skin cancer: Efficacy and cost comparisons. Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary? You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. The gel shrunk the participants’ tumors by 58.5%, and the ointment shrunk them by 47.7%. The study compared a gel with a compounded ointment. There is limited research suggesting that certain types of chemotherapy cream may help skin manifestations of other cancers.įor example, a 2013 study tested mechlorethamine cream in people with T cell lymphoma who had mycosis fungoides, which is a skin manifestation of lymphoma. Chemotherapy cream did not reduce the risk of keratinocyte carcinomas, but surgery did. The specific benefits of chemotherapy cream to prevent cancer depend on the type of cancer a doctor wants to prevent.įor example, a 2018 randomized clinical trial found a 75% reduction in the risk of developing squamous cell carcinoma in the first year following treatment with chemotherapy cream.Īlthough there was a slight reduction in the risk of basal cell carcinoma, the reduction was not statistically significant. Type of cancer may determine type of cream For example, doctors may prescribe 5FU cream to people with actinic keratosis, which is a type of sun-related skin damage that can lead to skin cancer. A 2019 study suggested that chemotherapy cream, when a person uses it with other treatments, can reduce the risk of developing skin cancer.Methotrexate cured 91% of cancers, compared with a higher cure rate of 98% for 5FU cream. Keratoacanthoma, which is a type of squamous cell carcinoma, had the highest cure rate with chemotherapy cream. A 2013 review looked at the use of chemotherapy cream to treat nonmelanoma skin cancers.A 2018 study involving 10 people with giant ocular surface squamous neoplasia, which is a type of skin cancer in the eye, assessed whether or not people needed surgery after using chemotherapy cream.The list below looks at what the research currently suggests. Topical chemotherapy may be an effective treatment option for certain cancers. In people who are too sick to undergo surgery or who wish to avoid surgery, chemotherapy cream may be an alternative. In some cases, a doctor may recommend using chemotherapy cream along with other treatments, such as surgery, to cure cancer and prevent it from coming back. The cream can also treat superficial types of skin cancer. A doctor may prescribe the cream to prevent certain lesions from becoming cancerous. A doctor may recommend chemotherapy eye drops or creams for cancers such as giant ocular surface squamous neoplasia.Ĭhemotherapy cream primarily treats cancers that affect the skin. Treating certain eye cancers: Certain cancers of the eye affect the skin of the eye.An older 2013 study concluded that topical chemotherapy is a safe and effective treatment option for mycosis fungoides. For example, T cell lymphoma can cause mycosis fungoides on the skin. Treating skin manifestations of other cancers: Some cancers that most people do not think of as skin cancer can affect the skin.Treating skin cancer: Some superficial forms of squamous cell and basal cell carcinoma may respond to chemotherapy cream.They may also suggest chemotherapy cream to treat large areas of sun-damaged skin with many precancers. Doctors sometimes prescribe ointment as an alternative to surgery to prevent cancer. Preventing skin cancer: Certain conditions, such as actinic keratosis, may become cancerous.Topical chemotherapy’s main uses include the following: ![]()
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![]() ![]() Meyers of recommends walking straight past the currency exchange counter upon arrival or in the airport baggage claim area. ![]() Airport or hotel exchange desk: Thumbs downĪirport exchange desks have some of the highest currency exchange rates, which means you pay more in dollars for conversion. He advises to read the fine print before purchasing. Heads up: Stallings warns that some prepaid debit cards can come with substantial fees, may not be usable everywhere and can leave you without funds if stolen. Prepaid cards are also convenient and safe since they reduce the need to carry as much currency and because a PIN is usually required to take out funds, Stallings says. You lock in the exchange rate at the time you load or reload it. Stallings says one upside to chip and PIN prepaid debit cards is they can be used in an automated payment machine to buy train tickets and to pay at unstaffed gas pumps and highway toll booths in Europe. They can be a good option for Americans traveling without a card using chip and PIN technology. It also snubs foreign transaction fees, and it charges the same rate as its regular credit card when converting currency.Īnother company offers a prepaid chip and PIN card, which allows travelers to load up on euros or pounds and use it like a debit card. For example, one major card company has started to offer prepaid cards free of the typical recurring fees. Prepaid cards for foreign use are becoming more widespread. Each bank has its own fees for ATM debit card withdrawals. Heads up: Meyers advises to call your bank before you go to ask about fee structures for ATM withdrawals. Stallings says if you take money out of a bank that has a relationship with your bank, you may be able to avoid some fees. "If your bank charges a flat rate for the withdrawal, you should certainly minimize your trips to the ATM by withdrawing larger sums each time you go," Meyers says.Īnd do your homework. To save money, keep ATM trips to a minimum. Some charge a flat rate, others charge a percentage, and still others charge both, Meyers says. "We consider the ATM to be the best choice in terms of convenience, exchange rates and fees," Meyers says.įees vary by institution. Using your debit card at ATMs is one recommended way to get cash when traveling abroad. The "PIN" refers to a personal identification number that the cardholder enters to authorize payment. The "chip" refers to a microchip embedded into the card to secure account information. Maria Brusilovsky, spokeswoman for Travelex Currency Services, says chip and PIN technology is now the preferred way of making credit card and debit card transactions in Europe, and some vendors only accept chip and PIN cards. In addition to cards without fees, think about getting a card with the latest technology. Others are just offering a few cards without foreign fees. Some major card companies have eliminated foreign transaction fees on all of their cards. You can save money on fees by making some calls before you go and knowing which cards to use," says Tom Meyers, editor in chief of, a guide to budget travel in Europe. "Most people have multiple credit cards, and each could have a different fee structure. Foreign transaction fees are a different story. Card companies base their exchange rates on wholesale prices offered to bigger institutions, so you're bound to get a fair rate. While some desks advertise "no-fee" exchanges, they still build in a hefty profit by offering a high rate.īefore your next trip, take a look at the best and worst methods of currency exchange by following Bankrate's "thumbs-up" or "thumbs-down" rating: Currency exchange methodsĬredit cards offer some of the lowest currency exchange rates. In lieu of foreign currency exchange desks at airports and major hotels, there are more convenient and cheaper ways to exchange currency, Stallings says. "Many options carry extraordinary hidden fees, and some places are just more difficult to negotiate since they are more cash-based than the typical American is used to," Stallings says. dollar abroad, update your knowledge of currency exchange.Īccording to Douglas Stallings, senior editor for Fodor's Travel, travelers need to be aware of currency exchange options abroad because of costs. If you're not careful, currency conversion fees can cost more than you expect. ![]() ![]() ![]() ![]() com 8 min 360p Huge Bouncing Titties Macromastia Busty 4 min 360p Class to Make butterscotch pudding with Breast Milk Breast Massage & Hand Expression Tutorial Boobs Tits p BBW MILF Strips To Show Off Her Massive Natural Tits Big Tits Bbw Massive Tits 5 min 360p Pregnant Big Tits BBW Titfucks Dildo Hypertrophy Milf Big 9 min 720p Insane unknown Russian BBW macromastia DOGGYSTYLE LOOP Russian Macromastia p Running with big boobs Tits Bbw Running p Girl With Huge Titties Fucked Doggy - Fucked Bbw Huge Titties 1 min 360p Miosotis and her Macromastia tits Macromastia Miosotis 11 min 720p Bbw Latina with HUGE TITS - Boobs Anal Hair 31 min 360p Eden Mor Teasing Bbw Bigtits 12 min 360p Euro MILF with macromastia h. 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Sucky” (now this is just getting ridiculous!) from her most magnificent mammaries with tell-tale drops of milk still clinging to her nipples, we can clearly make out the rings around her expansive areolas from the vacuum. :~(Īfter at long last the now milk-depleted Maxi removes “Mr. It’s no wonder the milking machines nipple cups steam up so quickly, as I imagine I’d get rather hot and bothered if put in the same position (but, alas, I am inferior in my own boob-sucking abilities to the extent that I can only suck one tit at a time). In this series, we get to watch every step of the way as Maxi presses the robotic boob sucker appendages firmly against both of her JJ-cup tits (although I’m upset it doesn’t show how she switches it on after doing so), the lucky machine then sucking her nipples hard into each sterile sheath and hungrily devouring every drop of delicious dairy goodness drawing down from lactating Maxi’s lovely lady lumps (I do so strive to be both overly-dramatic and anthropomorphic here). ![]() The sheer volume of milk weighing down her huge, pendulous 32JJ breasts seems to have increased exponentially as well since her last lactation videos (with her right breast seeming to produce significantly more milk than the left)! Okay, so perhaps it’s not really magical – what with maternal lactation being an entirely natural thing with the breast pump providing but a measure of mechanical suction support – it is nonetheless marvellous to see Maxi’s massive milkers expressing their delightful dairy goodness once again. ![]() ![]() ![]() Game and want to purchase it, you can support the developers by doing so here. ![]() This download is completely free and won't cost you a penny. All four Syberia Games are available in the Syberia Collection at a bargain price Kate Walker, a young ambitious lawyer from New York, is handed what seems to be a fairly straightforward assignment. Syberia 3: The Complete Journey Free Download Then, launch the game through the desktop shortcut. Double click inside the Syberia 3: The Complete Journey folder and run the setup application.zip” (To do this you will need 7-Zip, which you can get here, or you can use the built in windows extractor). zip file and click on “Extract to Syberia 3: The Complete Journey. Plunged into the heart of a world inhabited by a cast of interesting characters, youll discover and experience a fabulous tale as imagined by Benoit Sokal. Once the game is finished downloading, right click the. The next generation in adventure games, Syberia 3 takes you inside an enchanting, mysterious universe full of life for you to explore in 3D.Click on the front desk worker again, and choose the dialogue option Help. After abandoning the island, Kate is found dying on the edge of a river by the Youkole tribe, a nomadic people migrating with their snow ostriches. Exit out of the dialogue screen and click on your suitcase by the front door. About This Game Author and creator : Benoît Sokal Overview:The limitless imagination of Benoît Sokal continues in Syberia 3, focusing on an entirely new adventure. (You can use FDM which is free here, or any other download manager). Click on the back of the automaton man to insert the key. We recommend using a download manager for faster download speeds. Wait 5 seconds and click on the blue ‘download now’ button.Click the Download button below and you will be redirected to UploadHaven.Plunged into the heart of a world inhabited by a cast of interesting characters, you’ll discover and experience a fabulous tale as imagined by Benoit Sokal. Stuck in Valsembor village, together they must find a way to continue their journey in a race against their enemies and unexpected obstacles, not to mention Kate’s past, which catches up with her.The next generation in adventure games, Syberia 3 takes you inside an enchanting, mysterious universe full of life for you to explore in 3D. After abandoning the island, Kate is found dying on the edge of a river by the Youkole tribe, a nomadic people migrating with their snow ostriches. Syberia 4.3/5 English & 7 more 12. The limitless imagination of Benoît Sokal continues in Syberia 3, focusing on an entirely new adventure. ![]() ![]() ![]() Open the browser's settings page by pasting chrome://settings/ in the address bar and hitting enter.Since future files won't be listed there anymore once you have made the change, you are left with the following option: First, you can uncheck the option if the file type is still displayed in the download bar in Chrome. You probably wonder how to reset the feature if you made a mistake. The process needs to be repeated for other file types that you want executed automatically instead of just downloaded. ![]() Basically, any file type that is popular when it comes to malware distribution is blocked in Chrome.Ĭhrome will always load them in the default application that is associated with the selected file type the browser does not include options to select a different program for certain file types. File types that won't show the option include. The option to select "always open files of this type" is grayed out and not available for file types that Google considers dangerous. Note: Google Chrome prevents certain file types from opening automatically. All future files that you download that match the file extension will be run automatically on the system. This marks the file type so that it is run automatically whenever files matching it are downloaded to the local system.įor some file types, "always open with system viewer" is displayed instead this is the case for PDF documents. When it completes, click on the small arrow icon next to it and select the "always open files of this type" option. You should see it displayed in the downloads bar at the bottom of the page. Download the file type that you want opened automatically in the Chrome browser. Google Chrome on the other hand does not have that option, and the process is slightly more complex and less manageable than Firefox's. Just load about:preferences in the browser's address bar and locate the Applications section on the page to define rules for individual file types. Maybe PDF files, Usenet NZB files, or even videos that you download from the Internet.Īs a Firefox user, I'm spoiled by the options the web browser offers as you can set default actions for known file types easily on the Applications Settings page which you can open directly in the browser's settings. You too may have certain file types that you want opened directly. For instance, I prefer that torrent files get downloaded directly in a BitTorrent application as that's where I'd load them in anyway. That's true for most file types but not for all. ![]() ![]() ![]() Order your pair of prescription shooting glasses today at our amazing low prices, and you will see the improvement in your next action. Permanent hearing damage can occur when your ears are exposed to at least 140 decibels. Shooters prefer prescription sunglasses that make them forget they had anything on the face. Pro shooter Jessie Harrison wearing electronic hearing protection and clear eye protection. Lightweight material like plastic, aluminum or titanium are the best especially for long hours of activity. Yellow or brown on the other hand give a feeling of heightened adrenaline and visual action as they help improve contrast. ![]() Amber –brown is specifically important for blocking out blue light on a cloudy day improving contrast and depth perception to have a good hunting experience. Smoke, grey and grey-green block glare without changing color perception. Lens color is also an important feature for prescription sunglasses. It is important to choose shooting glasses prescription that give better front sight focus when aiming. The view is always important in the sport of shooting. This means that the peripheral view is unobstructed. ESS Eye Pro Crossbow Black (frame) - Smoke Gray (lens). The Radians Clay Pro Shooting glasses are frameless by design. 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This is simply because our eyes change as we age. ![]() The Perfect Prescription Shooting Glasses for AllĪ lot of people in the shooting space, especially when they get older have to look for bifocal prescription shooting glasses. ![]() ![]() Ultimately, the present lot confronts the viewer with Kline’s characteristic immediacy, yet what is most striking is the artist’s masterful use of color, which he continued to explore for the remainder of the decade. »įOUNDER AND DIRECTOR OF “MARISA DEL RE GALLERY” Furthermore, the bottom edge of the sheet is un-delineated, as Kline paints to the paper’s edge, allowing for drips of paint to fall beyond the border. Yet rather than serve as boundaries, they seem to extend past the confines of the perimeter, pushing the composition outwards beyond its domestic scale. Untitled (ZD 240) exemplifies Goldwater’s view – the perimeter is marked on the upper and right edges by swaths of red and white. Lieberman, An American Choice: The Muriel Kallis Collection, New York, 1981, p. In describing Franz Kline’s oeuvre, renowned art critic Robert Goldwater noted in 1967 that the power of these works is “generated from within, by an immense internal unit, a swath or rectangle, a closed shape or a crossed one, that pushes and extends the perimeter until it has sufficient room to take its proper form” (Robert Goldwater, quoted in William S. The sheet itself is entirely painted with an opaque, layered impasto surface, which showcases a boldness not typically likened to works on paper. Kline’s interest in the value of contrast is readily apparent in the present lot – here, deep greens pop against bright reds, vibrant blues are juxtaposed against pinks, and soft yellows are situated against blacks. Untitled (ZD 240) is a stunning example of one of Kline’s earliest experimentations with color, as thick swathes of greens, blues, reds and yellows extend across the composition, while drips of paint trickle down in overlapping forms. Focusing on black and white paintings in the first half of the decade, Kline increasingly re-introduced color into his palette in the mid-1950s and for the remainder of his career. Though he began as a figurative painter, Kline developed his mature style by 1950, creating entirely abstract works devoid of representation. New York artist Franz Kline’s painterly style embodies the speed, action, and immediacy that characterized the Abstract Expressionist movement of the 1940s and 1950s. Kline exhibited with The Greenberg Gallery from Septem– October 27, 1984 Possible Provenance: based on gallery advertisement taped on verso of artwork. I acquired this beauty from the son of a private collector in Los Angeles, who’s father died in 1999 & left him hundreds of mid century artworks. Verso has an art magazine advertisement for the María del Re Gallery, New York & The Greenberg Gallery, St. In good condition except for some scuffs and signs of aging, but overall, a fantastic piece. Franz Kline Mid Century Bold Color Oil on Illustration Board, Signature in middle left. ![]() ![]() Other artists he has collaborated with include Earl Sweatshirt, Armand Hammer, Hus Kingpin, Your Old Droog, Quelle Chris, Knxwledge, The Alchemist, and Evidence. In an interview with Complex Muggs described him as "one of the greatest talents to ever walk the earth". His 2019 album "Tuez-Les Tous" (translated to "Kill Them All") was fully produced by DJ Muggs of Cypress Hill. While he does produce solo material, he works closely and extensively with Tha God Fahim. He has drawn attention for the high prices he charges for his work (between US$300 and $3000), as well as his anonymity and reclusiveness. Goon Grizzle Goodbye Uncle Tom iGrade foreignOBJECTS Good Grease. He has drawn attention for the high prices he charges for his work (between US3), as well as his anonymity and reclusiveness. Mach-Hommy is a Haitian-American rapper from Newark, New Jersey. Son hooked it up with every Mach-Hommy release ever you know how hard this shit is to. Mach-Hommy is a Haitian-American rapper from Newark, New Jersey. (found via datpiff archive) Purchasing Supertape from Amazon helps support Album of the Year. iGrade, WellBreaducated, MayDay, Good Grease, Good Bye Uncle Tom, foreignOBJECTS, and others. "How Mach-Hommy and Westside Gunn Made 'Pray for Haiti' a Modern Hip-Hop Classic". Compilation of his 3-track EPs released on datpiff by Mach exclusively in 2013, but since removed. See how this album was rated and reviewed by the users of. "Mach-Hommy Drops 'Pray for Haiti' Album Executive Produced by Westside Gunn". User reviews & ratings for the album iGRADE by Mach-Hommy. "Mach-Hommy :: Pray For Haiti – RapReviews". Now, hes giving a rare peek into his interior life. "Mach-Hommy's 'Pray For Haiti' Album Is Hardcore Hip Hop With A Vanguard Punch". Mach-Hommy: The Man Behind the Mask Hes your favorite rappers favorite rapper, and released two stellar albums this year.
![]() ![]() With an annual calendar watch, you will be required to reset it once per year, every year, no matter what. Now, this is somewhat unrealistic with a mechanical movement, since variations in timekeeping will require adjustments to be made from time to time and if nothing else, regularly-scheduled maintenance will require the watch to come to a stop at some point or another however, the concept of full-autonomy is there. In theory, with a perpetual calendar, you will (almost) not need to ever reset the watch as long as it stays running. ![]() Both mechanisms account for the different number of days in the months however, only a perpetual calendar keeps track of leap years. While their names may be similar, an annual calendar complication is not the same thing as a perpetual calendar. Instead of discussing the watch itself, we are going to focus on the innovative Caliber 9001, its annual calendar complication, and what you need to do to get your Rolex Sky-Dweller displaying the correct information for the next twelve months. We have covered the Rolex Sky-Dweller extensively in previous articles, so if you are unfamiliar with the watch, read one of our other posts on it for more information regarding its design, its display layout, and how its fluted, ‘Ring Command’ bezel is not just for decorative purposes, but rather it is linked to the in-house Caliber 9001 movement within and is integral to the functionality of the watch. Combining a dual timezone display with GMT functionality and an annual calendar complication, the Rolex Sky-Dweller was designed to be the perfect luxury travel watch intended for traveling business executives and the jet-setting crowd. Strap/Bracelet: Oyster Bracelet, Leather Strap, Oysterflex BraceletĬlick here for our Ultimate Buying Guide on the Rolex Sky-Dweller.įirst launched in 2012, the Sky-Dweller is easily the most complex watch in Rolex’s current catalog. 10/10.Materials: Yellow Gold, White Gold, Everose Gold, Yellow Rolesor, White Rolesorįunctions: Time w/ Running Seconds, Date Display, Annual Calendar, Second Timezoneīezel: Ring Command, 18k Gold, Fluted Style It's frustrating, but not enough to detract from the rest. The only slight downside is the absence of things to do when you get stuck - the other characters won't talk to you unless it's plot-related, and will sometimes ignore you until you solve a particular puzzle. You have a great sidekick in the form of Joey, a great comic foil in the form of Lamb, and there's enough shifts and reveals in the story to keep you interested until the end. The Orwell-meets-Douglas-Adams storyline is dripping with black humour, and is a nice change from the self-referential gags of US graphic adventures. The graphics are among the best on the Amiga (and makes you wonder what Space Quest 4 would have been like in the hands of more capable converters). And a good conversion of a PC game, with graphics and gameplay both surviving intact. Not quite Monkey Island brilliant, but still a classic. ![]() ![]() ![]() They had to think about how you carve holes for doors and windows, or place objects on a wall that isn't flat. Though the first version of the tool was quick to develop, Massé said that it ended up as quite a challenge to make it work in the context of building a whole house. It would allow players to be more creative with flexible tools like that." I thought to myself that this would work really well for placing walls and building houses. "You can easily create straight or curved roads of any length without being restricted to a grid. "I got really inspired by Cities: Skylines and its road tool," he explained. This is an exciting development for veteran players of the Sims, where split-levels are only achievable by giving a house half a foundation, while curved walls are the stuff of dreams, so I asked Massé about them specifically. One watershed moment for me was the video showing how you can easily make split-level floors and curved walls in Paralives. Rather than, for example, buying a single bed or a double bed, you can just place a bed and resize it yourself. Screenshots and short videos, usually shared on Twitter, show simple but engaging things like the day and night cycle in the game, being able to resize objects at will, and a very fine level of control over everything in your mini-home. Paralives certainly has what we could call the Ooblets effect. Massé describes the marketing first approach of Patreon, where you build a community from the start of development, as "really motivating". One of the original artists, Roxane Morin, has now left, but the goal is to hit a team size of 10. ![]() And while Paralives was initially a solo dev project, Massé has been able to hire a small but dedicated team: 3D artist Léa Sorribès, communications director Christine Gariépy, and new programmer Anna Thibert, now collectively known as Paralives Studio. So they were able to know there was interest for the game really quickly and use it to build a community during development." He liked the idea of involving a community, so Patreon appealed more than working with a publisher. "As soon as they had their first screenshot of the game, they posted it on social media. "I was really inspired by what the Ooblets team did, which is the marketing first approach," Massé explained. It currently stands at nearly $36k per month, which is more than respectable for an indie game with no projected release date. He's always liked to work on his own projects, and consequently says he can "do a bit of everything." He continued: "I learned game design and 3D modelling by myself while working on side projects and game jams." Once he felt he had enough experience, he quit his job to make Paralives, launching the Patreon last year. Massé worked in the mobile games industry after graduating in 2014 (though he told me over email that he had been learning about programming and development since high school). So I reached out to Alex Massé, who we might term the lead developer, to ask him some Para-centric questions. After bunch of Sim YouTubers like lilsimsie did reaction videos and hyped it up, Paralives ended up with a lot of eyes on it, and I, in turn, hungered to know more. A few weeks back, though, there was a flurry of new interest when a new character creation video was released. Simthusiasts like myself have been quietly aware of Paralives for a small while now, mostly because of the very cool nature of the in-progress video clips that surface on a fairly regular basis. ![]() a life simulator? A Sims-like? (I know The Sims can't be the only game of its type, but it's dominated the market for so long that the only other one I can think of is that weird adult one where the entire point was having sex.) It, by which I really mean the teeny tiny dev team, is being funded on Patreon. If you're a fan of The Sims 4, or you know someone who is, or even if you just follow people who occasionally retweet simsposting into your timeline, you've probably seen something about Paralives by now. ![]() |
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