![]() ![]() Chemoprevention of basal and squamous cell carcinoma with a single dose of flourouracil, 5%, cream: A randomized clinical trial. Tolak (fluorouracil) cream, 4%, for topical use.Skin cancer treatment (PDQ)–Patient version. ![]() Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. Local treatment other than surgery for basal and squamous cell skin cancers.Topical chemotherapy in cutaneous T-cell lymphoma: Positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. Combination topical chemotherapy for the treatment of an invasive cutaneous squamous cell carcinoma. Topical and intralesional treatment of nonmelanoma skin cancer: Efficacy and cost comparisons. Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary? You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. The gel shrunk the participants’ tumors by 58.5%, and the ointment shrunk them by 47.7%. The study compared a gel with a compounded ointment. There is limited research suggesting that certain types of chemotherapy cream may help skin manifestations of other cancers.įor example, a 2013 study tested mechlorethamine cream in people with T cell lymphoma who had mycosis fungoides, which is a skin manifestation of lymphoma. Chemotherapy cream did not reduce the risk of keratinocyte carcinomas, but surgery did. The specific benefits of chemotherapy cream to prevent cancer depend on the type of cancer a doctor wants to prevent.įor example, a 2018 randomized clinical trial found a 75% reduction in the risk of developing squamous cell carcinoma in the first year following treatment with chemotherapy cream.Īlthough there was a slight reduction in the risk of basal cell carcinoma, the reduction was not statistically significant. Type of cancer may determine type of cream For example, doctors may prescribe 5FU cream to people with actinic keratosis, which is a type of sun-related skin damage that can lead to skin cancer. A 2019 study suggested that chemotherapy cream, when a person uses it with other treatments, can reduce the risk of developing skin cancer.Methotrexate cured 91% of cancers, compared with a higher cure rate of 98% for 5FU cream. Keratoacanthoma, which is a type of squamous cell carcinoma, had the highest cure rate with chemotherapy cream. A 2013 review looked at the use of chemotherapy cream to treat nonmelanoma skin cancers.A 2018 study involving 10 people with giant ocular surface squamous neoplasia, which is a type of skin cancer in the eye, assessed whether or not people needed surgery after using chemotherapy cream.The list below looks at what the research currently suggests. Topical chemotherapy may be an effective treatment option for certain cancers. In people who are too sick to undergo surgery or who wish to avoid surgery, chemotherapy cream may be an alternative. In some cases, a doctor may recommend using chemotherapy cream along with other treatments, such as surgery, to cure cancer and prevent it from coming back. The cream can also treat superficial types of skin cancer. A doctor may prescribe the cream to prevent certain lesions from becoming cancerous. A doctor may recommend chemotherapy eye drops or creams for cancers such as giant ocular surface squamous neoplasia.Ĭhemotherapy cream primarily treats cancers that affect the skin. Treating certain eye cancers: Certain cancers of the eye affect the skin of the eye.An older 2013 study concluded that topical chemotherapy is a safe and effective treatment option for mycosis fungoides. For example, T cell lymphoma can cause mycosis fungoides on the skin. Treating skin manifestations of other cancers: Some cancers that most people do not think of as skin cancer can affect the skin.Treating skin cancer: Some superficial forms of squamous cell and basal cell carcinoma may respond to chemotherapy cream.They may also suggest chemotherapy cream to treat large areas of sun-damaged skin with many precancers. Doctors sometimes prescribe ointment as an alternative to surgery to prevent cancer. Preventing skin cancer: Certain conditions, such as actinic keratosis, may become cancerous.Topical chemotherapy’s main uses include the following: ![]()
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